NFL Week 10 Predictions, Odds & Best Bets

The trade deadline has now come and gone for the 2026-27 NFL football season. There have been adjustments to NFL predictions following the trade deadline as some contenders were buyers, while other teams had a fire sale on their best remaining players. That will lead to bigger spreads in the football games the remainder of the season, as we will see a separation between the best teams and the worst teams in the league.

We are already seeing larger NFL spreads as a result of these deals and the state of these teams, so let’s get into the NFL picks for Week 10.

NFL Games This Week

Over half of the teams in the NFL have taken their bye week now. There will be 14 football games this week since there are four teams who are on a bye. The NFL football games on Thursday night and Monday night aren’t very appealing, but the Detroit Lions and New England Patriots will play in Munich, Germany on Sunday.

Top NFL Matchups to Watch

New England and Detroit will kick off the NFL matchups on Sunday. The Patriots will be playing their second game in Germany, while the Lions will be playing here for the first time. Both teams have a winning record and are seen as playoff contenders, but a lot of the shine is off New England after their Super Bowl appearance last season.

Minnesota made a big move on Tuesday. The Vikings traded a third-round pick to bring back Kirk Cousins after a dismal offensive showing on Monday Night Football. Early indications are that Cousins will be starting against the Green Bay Packers on Sunday afternoon, so many NFL predictions will be calling for the Packers to win this game.

Sunday afternoon will also give us a rekindling of one of the most intense non-division rivalries in the NFL. The Dallas Cowboys will welcome the San Francisco 49ers to the Big D, and San Francisco will look to strengthen its hold on the NFC with a win.

Thursday Night Football This Week

The New York Giants will look to extend their NFC East lead when they face the Washington Commanders on Thursday Night Football this week. This game will kick off at 8:15 p.m. ET on Prime Video, and both teams will look to avoid what happened when they met in Washington last month.

Thursday Night Football Matchup Preview

A win on Thursday Night Football would be huge for the New York Giants. The G Men are 5-2-1 and three games ahead of everyone except the Dallas Cowboys in the NFC East. A victory would move the Giants to 3-0-1 in the division, and that would make it harder for the Cowboys to run them down.

The Giants only scored three points in the first half when these teams met earlier in the season. Jameis Winston led the Giants back with three second half touchdown passes, and then a comedy of errors ensued in overtime. New York missed a 46-yard field goal and Cam Skattebo fumbled on Washington’s 24-yard line with two minutes remaining to give the Commanders a chance. Washington moved the ball down to New York’s 24-yard line before Jayden Daniels was inexplicably sacked, allowing the clock to run out.

Jaxson Dart is on injured reserve, and the Giants traded for J.J. McCarthy after some inconsistent performances from Winston. McCarthy has been the Giants’ starter for their last two games, but he was injured in New York’s win over Philadelphia and is questionable to play on Thursday.

Thursday Night Football Predictions & Best Bets

New York Giants 24, Washington Commanders 21

Although many people don’t expect there will be a lot of points in the NFL game tonight, I believe it will go Over the NFL betting total. Four of the last five New York Giants’ games have had at least 48 total points, and the Commanders can do enough to put points on the board despite an abysmal running game.

When it comes to a side, the decision is much more difficult. Jayden Daniels will be the best quarterback on the field, but the Giants have the advantage in most of the other NFL matchups. Washington has had a hard time running the ball without Jacory Croskey-Merritt, and the Commanders don’t have top receiver Terry McLaurin either.

The Giants have the worst red zone defense in the league, and the Commanders aren’t far behind them. There might not be many scoring opportunities in this game, but I think there will be enough chances for the game to go over the total.

PASS on New York Giants -2 vs. Washington Commanders

OVER 41.5 in New York Giants vs. Washington Commanders

Sunday Night Football This Week

First place in the AFC North will be on the line in this week’s Sunday Night Football game between the Cincinnati Bengals and Pittsburgh Steelers. This game is scheduled to kick off at 8:20 p.m. ET on NBC.

Sunday Night Football Matchup Preview

Pittsburgh knocked off Cincinnati at home in Week 3 behind a strong offensive performance. Aaron Rodgers threw for 292 yards with three touchdowns and an interception, while Jaylen Warren ran the ball 17 times for 127 yards. The Steelers had over 400 total yards of offense, and they averaged 7.0 yards per play.

Joe Burrow had a solid performance in the loss completing 28 of 37 passes for 282 yards and three touchdowns. However, Burrow fumbled in Pittsburgh territory in the final minute to end any hope of a Bengals’ comeback. It was Cincinnati’s second fourth quarter fumble, and that enabled the Steelers to get the win.

The Steelers have had an extra week to prepare for their rematch with the Bengals. A second victory over Cincinnati would give Pittsburgh the tiebreaker in the event these teams finished with the same record, and that would be a massive advantage.

Sunday Night Football Predictions & Best Bets

Cincinnati Bengals 34, Pittsburgh Steelers 24

Pittsburgh might have the rest advantage, but Cincinnati is the play here. The Steelers have had the edge in the NFL matchups against most of their opponents, but this team is pretty much smoke and mirrors. They have been very fortunate with their schedule, and this might be the worst 10-win team in the NFL at the end of the season.

Although the Bengals are one-dimensional on offense, they are exceptionally good at moving the ball through the air. Burrow leads the league in completion percentage and passing yards per game, and this offense ranks in the top five in most categories. Pittsburgh does not have the talent at defensive back to match up with Ja’Marr Chase and Tee Higgins, so I am expecting a big game from Burrow.

CINCINNATI -3.5 in Cincinnati Bengals vs. Pittsburgh Steelers

OVER 48.5 in Cincinnati Bengals vs. Pittsburgh Steelers

Monday Night Football This Week

The only winless team left in the NFL will be featured on Monday Night Football to close out the week. The Los Angeles Chargers are looking to get their first win of the season against the Baltimore Ravens on MNF tonight. It’s been an extremely disappointing season for both preseason Super Bowl contenders, and this game has one of the lowest totals of the week. Kickoff for this game will be at 8:15 p.m. ET on ESPN and ABC.

Monday Night Football Matchup Preview

This appeared to be one of the best primetime NFL matchups early in the season. The Baltimore Ravens and Los Angeles Chargers were both on the short list of Super Bowl contenders in the AFC. However, Baltimore’s hopes have been largely dashed due to multiple injuries to Lamar Jackson, while the Chargers have just had a complete collapse.

Justin Herbert is listed as questionable in this game, but Jim Harbaugh stated that he should be able to play during Tuesday’s press conference. Top receiver Ladd McConkey is also listed as questionable due to back spasms, and he missed last week’s game against Houston. There are some major concerns along the offensive line too with Trevor Penning, Tyler Biadasz, and Trey Pipkins III on injured reserve and left tackle Joe Alt struggling mightily after making his first Pro Bowl last season.

Baltimore is not the same team without a healthy Lamar Jackson. Jackson and top backup Tyler Huntley are both on injured reserve, so the Ravens went out and acquired Jacoby Brissett from Arizona. Brissett is a reliable veteran that will be asked to keep the Ravens’ playoff hopes alive while the team waits for Jackson to return.

Monday Night Football Predictions & Best Bets

Los Angeles Chargers 19, Baltimore Ravens 16

Everyone is expecting too much out of Baltimore’s offense. The Ravens absolutely needed to trade for a veteran signal caller after Joe Fagnano struggled mightily in his two appearances, but Jacoby Brissett does not bring the same athleticism as Lamar Jackson or Tyler Huntley. Brissett is no longer a mobile threat, averaging just 3.0 YPC this season, and he averaged just 5.6 YPA while throwing seven picks for Arizona.

The Los Angeles Chargers have been incredibly underwhelming and have struggled to find the end zone, but I believe they can do enough on Monday night to secure their first win of the season. Three of Baltimore’s starters in the secondary are banged up and questionable to play, so Justin Herbert might be able to move the ball through the air.

LOS ANGELES +4 in Baltimore Ravens vs. Los Angeles Chargers

UNDER 38.5 in Baltimore Ravens vs. Los Angeles Chargers

NFL Predictions for This Week

There is no prevailing theme in this week’s picks for NFL games, but we do have plenty of NFL predictions that can give you a rooting interest in every time slot.

Predictions for the Biggest Games

New England Patriots 27, Detroit Lions 24

Drake Maye and the New England Patriots haven’t looked great for the last month. The Patriots are 2-2 over this stretch, but those wins came against the New York Jets and Miami Dolphins, and they were both one-score games. Maye is tied with Justin Herbert for the league lead in picks despite being sacked just 20 times, but his QBR ranks fifth in the NFL. Detroit looks more impressive on paper with four straight victories, but the Lions have some major depth issues on defense right now.

Green Bay Packers 20, Minnesota Vikings 13

One of my best NFL picks this week is the Under in this game. Minnesota has been great defensively this season. Defensive coordinator Brian Flores has the Vikings ranked first in scoring defense (14.5 PPG) and second in total defense (280.0 YPG), and they have been superb in the red zone. The offense has been another story, and Kirk Cousins won’t be able to change things overnight. Minnesota will have to install a very vanilla gameplan since Cousins has less than a week to prepare, so that behooves an Under bet against the NFL betting odds.

San Francisco 49ers 30, Dallas Cowboys 27

This will be one of the most watched NFL matchups of Week 10 as the San Francisco 49ers are the current Super Bowl favorites. San Francisco has only played two true road games so far this season, and the 49ers won their first road game by a field goal and lost on the road to the Atlanta Falcons before their bye week. That is one of the reasons why I believe that Dallas can keep it within the number on Sunday afternoon.

Potential Upsets This Week

New England is ranked three spots ahead of Detroit in DVOA. The Patriots have been maligned for only beating the New York Jets and Miami Dolphins over the last month, but two of the Lions’ wins were against those same teams, and Detroit didn’t look too impressive against Miami last week either. Detroit ranks dead last in pass defense, and the loss of All-Pro linebacker Jack Campbell is a significant one. Additionally, the Lions have been incredibly fortunate on special teams with opponents making just over 57% of their field goals against Detroit on the year.

Dallas has the potential to knock off San Francisco too. The 49ers have not looked great outside the Bay Area this season, and Dak Prescott is putting together a fine year. The big issue for the Cowboys has been their defense this season, but there are reasons to believe Dallas can possibly beat San Francisco. The 49ers allow more sacks per drop back than any other team in the league, and they do not have a reliable field goal kicker.

NFL Best Bets Today and This Week

Without further ado, here are the NFL matchups I am looking at when selecting my NFL best bets today.

Spread and Moneyline Best Bets

Maybe the strongest of my NFL picks this week is Green Bay to cover the number against Minnesota. The Packers have really turned a corner after some offensive line injuries hampered this offense, and Jordan Love has led Green Bay to wins in five of their last six games.

I am also going to back the New England Patriots in my NFL predictions for Week 10. New England was dead in the water after Drake Maye threw three picks in the first half against Green Bay last Sunday, but I don’t think he will be as mistake-prone against a vulnerable Detroit secondary.

Totals and Betting Value

The Under in the Green Bay-Minnesota game is my strongest total play of the week. This line has been influenced by the season opener between the Packers and the Vikings having a combined 61 points, but Minnesota has not scored more than 23 points in a game since that point. Interestingly enough, the Vikings haven’t allowed more than 23 points all season either.

NFL Picks and Parlays

Thursday, November 12, 2026
OVER 41.5 in New York Giants vs. Washington Commanders

The total in this game is too low even though there are valid quarterback concerns for the New York Giants. It goes against my NFL betting tips of preferring Unders on Thursday Night Football, but the value is in the Over in this game.

Sunday, November 15, 2026
New England Patriots ML +134 vs. Detroit Lions

Jahmyr Gibbs is one of the best dual threat running backs in NFL football today. Gibbs already has over 1,100 total yards from scrimmage and 11 total touchdowns this season, but Mike Vrabel knows how to limit a team’s most talented player and will stymie Detroit’s offense.

Green Bay Packers -3.5 vs. Minnesota Vikings
UNDER 42 in Green Bay Packers vs. Minnesota Vikings

Currently, this is the game I feel the strongest about this week, so I have two NFL best bets on the Green Bay-Minnesota game. People are continuing to doubt Matt LaFleur and the Green Bay Packers even though LaFleur has won over 65% of his games.

Dallas Cowboys +4.5 vs. San Francisco 49ers

I’m not going to call for Dallas to pull off the upset, but I do believe that the Cowboys can use their home field advantage to stay within the number here.

Cincinnati Bengals -3,5 vs. Pittsburgh Steelers
OVER 48.5 in Cincinnati Bengals vs. Pittsburgh Steelers

Pittsburgh is not as good as its 6-2 record indicates, and the Steelers are not as good on defense as you might think given their numbers.

Monday, November 16, 2026
Los Angeles Chargers +4 at Baltimore Ravens
UNDER 38.5 in Baltimore Ravens vs. Los Angeles Chargers

My final NFL picks for Week 10 are the Los Angeles Chargers and the Under in the Monday Night Football game. Justin Herbert has not been good, but it's hard to have this much faith in Jacoby Brissett learning a new system on the fly.

NFL Parlay Ideas for the Week

When looking at NFL picks and parlays this week, I am going against teams with new quarterbacks. Too much respect is being given to Baltimore and Minnesota, and I expect Jacoby Brissett and Kirk Cousins to have a much harder time than the oddsmakers think with less than a week to prepare for their first games with their new teams.

What to Consider Before Building an NFL Parlay

When constructing an NFL parlay, you need to avoid a negative correlation. Favorites should be parlayed with Overs, and Underdogs should be parlayed with Unders. There is a negative correlation if you are betting on a 10-point favorite and an Under in a game, as there are fewer winning final scores.

Key Factors Behind This Week’s NFL Predictions

My NFL predictions for Week 10 don’t follow a specific pattern, but many of my top NFL picks this week are against teams with brand new quarterbacks.

Injuries and Player Availability

We have seen some major line moves in NFL football betting this season due to quarterback injuries. Baltimore is not the same without Lamar Jackson, Philadelphia is a shadow of itself without Jalen Hurts, and Chicago did not look like a Super Bowl contender with an injured Caleb Williams.

Rest, Travel and Recent Team Form

I don’t like either of the teams coming off bye weeks in the NFL matchups for Week 10. Pittsburgh is going to have its hands full with Cincinnati, and it’s hard to back Tennessee no matter the situation given the turmoil within that organization.

Final NFL Weekly Preview

Those are my NFL best bets today. I have a few potential same-game parlays with the NFL predictions this week, and there are NFL picks available for every time slot in Week 10.

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